|
KMID : 1149220220300040249
|
|
Korean Journal of Oriental Medical Prescription
2022 Volume.30 No. 4 p.249 ~ p.257
|
|
|
Evaluation of Immunomodulatory and Biological Effects of Aquilaria crassna Extracts
|
|
Hwang You-Lim
Kim Kwang-Youn
Yu Sun-Nyoung
Park Kwang-Il
Ahn Soon-Cheol
|
|
|
Abstract
|
|
|
Objectives : Aquilaria crassna is a traditional herbal medicine, which is used to treat allergies, diabetes, neurological diseases. Recently, Aquilaria crassna extracts have been reported in anti-bacterial and anti-inflammatory activities. In this study, various solvents fraction of Aquilaria crassna were investigated on various physiological activities.
Methods : According to the polarity, the solvents fraction of Aquilaria crassna were confirmed through TLC, and the activities of the extracts were confirmed in anti-diabetes, anti-obesity, whitening, anti-gout, and anti-inflammation.
Results : TLC results showed that ACM and ACM/E have similar patterns and most of the components were transferred to ACM/E. Treatment with ACM and ACM/E fraction were significantly decreased the generation of NO in lipopolysaccharide (LPS)-stimulated macrophage cells. Analysis of biological activities such as α-glucosidase, protein tyrosine phosphatase (PTP1B), tyrosinase, xanthine oxidase (XO) and pancreatic lipase inhibition, showed that ACM and ACM/E have more inhibitory effects than other fractions.
Conclusions : Therefore, the results of the present study clearly demonstrate that Aquilaria crassna and its constituents might be beneficial in the prevention or treatment of immune-regulating effects.
|
|
|
KEYWORD
|
|
|
Aquilaria crassna, Biological activity, immunomodulatory activity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|